Fedora 45 was released yesterday, November 3rd. I was an early bird and I upgraded my home system (Fedora Sway Spin) to that. Upgrade was smooth, except that after the first boot it did not recognize my AMD Radeon R5 430 2GB GDDR5 Graphics Card. The monitor on the mainboard display port came up fine. I did a restart and it has been working since.
In due time I will upgrade my work laptop.