That is always a bit of a tricky one for me—I love the power and simplicity of a DE such as MATE or Xfce, but I also appreciate the modernity of GNOME or KDE (such as Wayland support). I genuinely wouldn’t know! I think I prefer the GTK ecosystem of apps, but still…
I currently run Fedora GNOME on my main build, but Debian MATE is looking very attractively towards me. So perhaps that could be my alternative—I think I’d try that out first if Fedora and GNOME were to disappear.