I’ll say this: if you get a system with reasonable performance, a Linux Mint based system is solid, visually pleasing, and has a good community behind it. On the other hand, comparing it side by side, the same system built straight from Debian, possibly with a few less resource intensive scripts and fancy graphics will reward you with better memory utilization, and under a careful eye, slightly better performance, though on a mid to high end system these factors are insignificant. Both Debian and Linux Mint are solid distributions.
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